CYTOGENETICAL EFFECTS OF INORGANIC PYROPHOSPHATE AND 5-FLUORO DEOXYURIDINE
نویسندگان
چکیده
منابع مشابه
The clinical effects of prolonged intravenous infusion of 5-fluoro-2'-deoxyuridine.
tinuous) i.v. and intra-arterial infusion of cancer chemo therapeutic compounds and reported the profound altera tions of the biologic effects of several of these compounds in terms of dose-toxicity response and anti-tumor effects that result from these methods of administration. We have previously reported the rationale for prolonged ther apy and clinical studies of the effects of the continuo...
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We have attempted to evaluate the degree to which hepatic arterial infusion of 5-fluoro-2 -deoxyuridine (FdUrd) or 5-fluorouracil produces higher hepatic and lower systemic drug concentrations than are achieved with corresponding peripheral venous infusions. Hepatic arterial catheters were placed for therapy in 15 patients with primary or metastatic liver cancer. Temporary he patic venous cathe...
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5-Carboxy-2'-deoxyuridine (5-COOH-2'-dUrd) is a product of the base-catalyzed hydrolysis of 5-trifluoromethyl-2'-deoxyuridine. Hydrolysis of 5-trifluoromethyl-2'-deoxyuridine to 5-COOH-2'-dUrd in phosphate-buffered saline was kinetically first order and was pH dependent. At 37 degrees C and pH 7.0, 7.5, and 8.0, hydrolysis occurred with rate constants of 4.19 x 10(-5), 9.30 x 10(-5), and 1.61 x...
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Background & Aims: Drugs are highly active due to their many functional groups and can be easily destroyed by stomach acid and excreted before reaching target tissue. Thus, by encapsulating, a sheath is placed around drug to reduce reactivity of the drug due to stereo electronic resonance with nanotube and consequently drug stays longer in body. As a result, you can consume a smaller dose of dr...
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Protein in vitro inhibition of thymidylate synthase (5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) by 5-fluoro-2'-deoxyuridylate requires 5,10-methylenetetrahydrofolate. The cytoxicity of 5-fluoro-2'-deoxyuridine towards cultured L1210 mouse leukemia cells is reduced when intracellular reduced folates are depleted, either by limiting the source in media or by inhibition ...
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ژورنال
عنوان ژورنال: Hereditas
سال: 2009
ISSN: 0018-0661
DOI: 10.1111/j.1601-5223.1968.tb02173.x